The Arizona Diamondbacks' Opening Day plans may be disrupted by injuries to key players. Catcher and designated hitter Adrian Del Castillo, who made a strong debut in 2024, is dealing with a left calf injury. Manager Torey Lovullo confirms Del Castillo will miss most of spring training and will be reassessed closer to the regular season's start. With Opening Day on March 26, the team faces a challenge in filling the designated hitter (DH) role. Del Castillo's injury, along with Corbin Carroll's and Lourdes Gurriel Jr.'s potential absence, means the Diamondbacks must be creative with their lineup. Ketel Marte will take on the DH role periodically, while Pavin Smith and Carlos Santana will play first base. Tyler Locklear, who joined the team in the Eugenio Suarez trade, is also out until May or June due to shoulder and elbow surgeries. The team's depth at first base has been bolstered by the addition of Carlos Santana this offseason, but the injury concerns of Del Castillo and Locklear could impact the team's performance and strategy.